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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Fields Molecular and Chemical Life Science :Chemical Biology Research Bioactive Molecules HOME Research Laboratories Bioactive Molecules JAPANESE Bioactive Molecules Novel strategies for small molecule drug discovery   Traditional small molecule drug discovery strategies rely on the “lock and key” theory, which specifies that small molecule drugs bind to target proteins and modulate their functions. However, many disease-related proteins, including substrate binding proteins, aggregation-prone proteins, and protein-protein interactions cannot be predicted by the lock and key mechanism. Therefore, we discovered novel strategies that employ methods of organic chemistry, and molecular and cellular biology to regulate these proteins. We developed a novel strategy for small molecule drug discovery, in which, degradation of target proteins is based on the use of small hybrid molecules composed of a ligand for the target protein and another for ubiquitin ligase. These hybrid small molecules direct the ubiquitin ligase towards the target protein, leading to selective degradation by the ubiquitin-proteasome system. In addition, we demonstrated that this strategy could be an effective therapeutic approach for neurodegenerative diseases. Aqueous solubility is essential for drug candidates, and improving aqueous solubility of bioactive compounds is a major concern for medicinal chemists. We have proposed strategies for improving aqueous solubility by modifying molecules using certain methods that would decrease intermolecular interaction. Our results indicate that these strategies can increase the aqueous solubility of molecules although their hydrophobicities increase concomitantly.   Research Overview Our group studies medicinal chemistry/chemical biology based on the pharmaceutical industry needs. Faculty Members Professor ISHIKAWA Minoru More Associate Professor SATO Shinichi (C) More Assistant Professor TOMOSHIGE Shusuke More Medicinal Chemistry and Chemical Biology based on targeted protein degradation technology ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache