KUHL(クール)総合｜エアロパーツ・コンプリートカー

--> Juntendo University, Tokyo, established in 1838. English Chinese Indonesian Korean Japanese About Juntendo Study Research Hospital information International Center Home Research Research Support Center Laboratory of Molecular and Biochemical Research Laboratory of Molecular and Biochemical Research  Introduction   Research   Publications   Laboratory  Japanese      Index Members’ Publications 2022 Niba, ETE., Nishio, H., Wijaya, YOS., Ar Rochmah, M., Takarada, T., Takeuchi, A., Kimizu, T., Okamoto, K., Saito, T., Awano, H., Takeshima, Y., and Shinohara, M. Stability and oligomerization of mutated SMN protein determine clinical severity of spinal muscular atrophy. Genes. 13, 205 (2022) Wijaya YOS, Niba ETE, Nishio H, Okamoto K, Awano H, Saito T, Takeshima Y, Shinohara M. High concentration or combined treatment of antisense oligonucleotides for spinal muscular atrophy perturbed SMN2 splicing in patient fibroblasts. Genes. 13, 685 (2022) 2021 Ikeda, Y., Kaga, M., Koide, H., and Ikeda, S. A novel deletion mutation in the ATP2C1 gene in a case of generalized Hailey-Hailey disease possibly aggravated by scabies infection. J. Dermatol. 48, e178-179 (2021) Kamijo, S., Hara, M., Suzuki, M., Nakae, S., Ogawa, H., Okumura, K., and Takai, T. Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization. J. Invest. Dermatol. 141, 105-113 (2021) Yoneyama, T., Nakano, N., Hara, M., Yamada, H., Izawa, K., Uchida, K., Kaitani, A., Ando, T., Kitaura, J., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T. Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J. Allergy Clin. Immunol. 147, 1063-1076 (2021) Yashiro, T., Yamamoto, M., Araumi, S., Hara, M., Yogo, K., Uchida, K., Kasakura, K., and Nishiyama, C. PU.1 and IRF8 modulate activation of NLRP3 inflammasome via regulating its expression in human macrophages. Front. Immunol. 12, 649572 (2021) Nakano, N., Saida, K., Hara, M., Izawa, K., Ando, T., Kaitani, A., Kasakura, K., Yashiro, T., Nishiyama, C., Ogawa, H., Kitaura, J., and Okumura, K. Mucosal mast cell-specific gene expression is promoted by interdependent action of Notch and TGF-β signaling. J. Immunol. 207, 3098-3106 (2021) Niba, ETE., Awano, H., Lee, T., Takeshima, Y., Shinohara, M., Nishio, H., and Matsuo, M. Dystrophin Dp71 subisoforms localize to the mitochondria of human cells. Life. 11, 978 (2021) Niba, ETE., Nishio, H., Wijaya, YOS., Lai, PS., Tozawa, T., Chiyonobu, T., Yamadera, M., Okamoto, K., Awano, H., Takeshima, Y., Saito, T., and Shinohara, M. Clinical phenotypes of spinal muscular atrophy patients with hybrid SMN gene. Brain Dev. 43, 294-302 (2021) Niba, ETE, Wijaya, YOS., Awano, H., Taniguchi, N., Takeshima, Y., Nishio, H., and Shinohara, M. DBS screening for glycogen storage disease type 1a: detection of c.648G>T mutation in G6PC by combination of modified competitive oligonucleotide priming-PCR and melting curve analysis. Int J Neonatal Screen. 7, 79 (2021) Kimizu, T., Ida, S., Okamoto, K., Awano, H., Niba, ETE., Wijaya, YOS., Okazaki, S., Shimomura, H., Lee, T., Tominaga, K., Nabatame, S., Saito, T., Hamazaki, T., Sakai, N., Saito, K., Shintaku, H., Nozu, K., Takeshima, Y., Iijima, K., Nishio, H., and Shinohara, M. Spinal muscular atrophy: diagnosis, incidence, and newborn screening in Japan. Int J Neonatal Screen. 7, 45 (2021) Wijaya, YOS., Är Rochmah, M., Niba, ETE., Morisada, N., Noguchi, Y., Hidaka, Y., Ozasa, S., Inoue, T., Shimazu, T., Takahashi, Y., Tozawa, T., Chiyonobu, T., Inoue, T., Shiroshita, T., Yokoyama, A., Okamoto, K., Awano, H., Takeshima, Y., Saito, T., Saito, K., Nishio, H., and Shinohara, M. Phenotypes of SMA patients retaining SMN1 with intragenic mutation. Brain Dev. 43, 745-758 (2021) Wijaya, YOS., Nishio, H., Niba, ETE., Shiroshita, T., Kato, M., Bouike, Y., Tode, C., Ar Rochmah, M., Harahap, NIF., Nurputra, DK., Okamoto, K., Saito, T., Takeuchi, A., Lai, PS., Yamaguchi, S., and Shinohara, M. Dried blood spot screening system for spinal muscular atrophy with allele-specific polymerase chain reaction and melting peak analysis. Genet Test Mol Biomarkers. 25, 293-301 (2021) Wijaya, YOS., Nishio, H., Niba, ETE., Okamoto, K., Shintaku, H., Takeshima, Y., Saito, T., Shinohara, M., and Awano, H. Detection of spinal muscular atrophy patients using dried saliva spots. Genes. 12, 1621 (2021) Wijaya, YOS., Niba, ETE., Yabushita, R., Bouike, Y., Nishio, H., and Awano, H. Glycogen storage disease type Ia screening using dried blood spots on filter paper: application of COP-PCR for detection of the c.648G>T G6PC gene mutation. Kobe J Med Sci. 67, E71-E78 (2021) 2020 Xiao, Y., Mo, W., Jia, H., Yuc, D., Qiud, Y., Jiao, Y., Zhu, W., Koide, H., Cao, J., and Zhang, S. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury. J. Dermatol. Sci. 97, 152-160 (2020) Hashimoto, R., Kakigi, R., Miyamoto, Y., Nakamura, K., Itoh, S., Daida, H., Okada, T., and Katoh, Y. JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages. Eur. J. Pharmacol. 871, 172940 (2020) Eshima, H., Tamura, Y., Kakehi, S., Kakigi, R., Hashimoto, R., Funai, K., Kawamori, R., and Watada, H. A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca²&＃8314; release capacity in the skeletal muscle of aged mice. J. Appl. Physiol. (1985) 128, 1153 (2020) Joshi, S., Kitagawa, A., Jacob, C., Hashimoto, R., Dhagia, V., Ramesh, A., Zheng, C., Zhang, H., Jordan, A., Waddell, I., Leopold, J., Hu, C., McMurtry, I., D'Alessandro, A., Stenmark, K., and Gupte, S. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am. J. Physiol. Lung Cell Mol. Physiol. 318, L773 (2020) Hashimoto, R., Lanier, G., Dhagia, V., Joshi, S., Jordan, A., Waddell, I., Tuder, R., Stenmark, K., Wolin, M., McMurtry, I., and Gupte, S. Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 318, L386 (2020) Niba, ETE., Awano, H., Nagai, M., Taniguchi, M., Itoh, K., Nishimura, N., Iijima, K., Nishio, H., and Matsuo, M. Pilocytic astrocytoma tissue from a 25-year-old patient with Duchenne muscular dystrophy expresses the DMD transcript but not protein. Clin Res Pediatr. 3, 1-9 (2020) Rochmah, MA., Wijaya, YOS., Harahap, NIF., Tode, C., Takeuchi, A., Ohuchi, K., Shimazawa, M., Hara, H., Funato, M., Saito, T., Saito, K., Lai, PS., Awano, H., Shinohara, M., Nishio, H., and Niba ETE. Phosphoethanolamine elevation in plasma of spinal muscular atrophy type 1 patients. Kobe J Med Sci. 66, E1-E11 (2020) Wijaya, YOS., Purevsuren, J., Harahap, NIF., Niba, ETE., Bouike, Y., Nurputra, DK., Rochmah, MA., Thursina, C., Hapsara, S., Yamaguchi, S., Nishio, H., and Shinohara, M. Assessment of spinal muscular atrophy carrier status by determining SMN1 copy number using dried blood spots. Int J Neonatal Screen. 6, 43 (2020) 2019 Shoji, Y., Takamura, H., Ninomiya, I., Fushida, S., Tada, Y., Yokota, T., Ohta, T., and Koide, H. The embryonic stem cell-specific transcription factor ZFP57 promotes liver metastasis of colorectal cancer. J. Surg. Res. 237, 22-29 (2019) Maruyama, N., Takai, T., Kamijo, S., Suchiva, P., Ohba, M., Takeshige, T., Suzuki, M., Hara, M., Matsuno, K., Harada, S., Harada, N., Nakae, S., Sudo, K., Okuno, T., Yokomizo, T., Ogawa, H., Okumura, K., and Ikeda, S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy 74, 2237-2240 (2019) Yoshikawa, S., Oh-Hora, M., Hashimoto, R., Nagao, T., Peters, L., Egawa, M., Ohta, T., Miyake, K., Adachi, T., Kawano, Y., Yamanishi, Y., and Karasuyama, H.  Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.  Sci. Signal. 12, eaav2060 (2019) Hashimoto, R., Miyamoto, Y., Itoh, S., Daida, H., Okada, T., and Katoh, Y.  Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca²&＃8314;-enhanced adipogenesis in bone marrow stromal cells.  J. Physiol. Sci. 69, 741 (2019) Niba, ETE., Ar Rochmah, M., Harahap, NIF., Awano, H., Morioka, I., Iijima, K., Takeshima, Y., Saito, T., Saito, K., Takeuchi, A., Lai, PS., Bouike, Y., Matsuo, M., Nishio, H., and Shinohara, M. Spinal muscular atrophy: new screening system with real-time mCOP-PCR and PCR-RFLP for SMN1 deletion. Kobe J Med Sci. 65, E44-E48 (2019) Niba, ETE., Ar Rochmah, M., Harahap, NIF., Awano, H., Morioka, I., Iijima, K., Takeshima, Y., Saito, T., Saito, K., Takeuchi, A., Lai, PS., Bouike, Y., Matsuo, M., Nishio, H., and Shinohara, M. Spinal muscular atrophy: Advanced version of screening system with real-time mCOP-PCR and PCR-RFLP for SMN1 deletion. Kobe J Med Sci. 65, E49-E53 (2019) Takeuchi, A., Tode, C., Nishino, M., Wijaya, YOS., Niba, ETE., Awano, H., Takeshima, Y., Saito, T., Saito, K., Lai, PS., Bouike, Y., Nishio, H., and Shinohara, M. Newborn Screening for Spinal Muscular Atrophy: DNA Preparation from Dried Blood Spot and DNA Polymerase Selection in PCR. Kobe J Med Sci. 65, E95-E99 (2019) Shinohara, M., Niba, ETE., Wijaya, YOS., Takayama, I., Mitsuishi, C., Kumasaka, S., Kondo, Y., Takatera, A., Hokuto, I., Morioka, I., Ogiwara, K., Tobita, K., Takeuchi, A., and Nishio, H.; SMA-NBS PILOT STUDY GROUP. A novel system for spinal muscular atrophy screening in newborns: Japanese pilot study. Int J Neonatal Screen. 5, 41 (2019) Takeuchi, A., Tode, C., Nishino, M., Wijaya, YOS., Niba, ETE., Awano, H., Takeshima, Y., Saito, T., Saito, K., Lai, PS., Bouike, Y., Nishio, H., and Shinohara, M. Newborn screening for spinal muscular atrophy: DNA preparation from dried blood spot and DNA polymerase selection in PCR. Kobe J Med Sci. 65, E95-E99 (2019) Wijaya, YOS., Niba, ETE., Ar Rochmah, M., Harahap, NIF., Awano, H., Takeshima, Y., Saito, T., Saito, K., Takeuchi, A., Lai, PS., Bouike, Y., Nishio, H., and Shinohara, M. Nested PCR amplification may secure DNA template quality and quantity in real- time mCOP-PCR screening for SMA. Kobe J Med Sci. 65, E54-E58 (2019) 2018 Kinjo, T., Sun, C., Ikeda, T., Ikegami, T., Tada, Y., Akagi, T., Yokota, T., and Koide, H. Platelet-derived growth factor-C functions as a growth factor in mouse embryonic stem cells and human fibrosarcoma cells. Cell. Mol. Biol. Lett. 23, 8 (2018) Kadoguchi, T., Shimada, K., Koide, H., Miyazaki, T., Shiozawa, T., Takahashi, S., Aikawa, T., Ouchi, S., Kitamura, K., Sugita, Y., Hamad, A.S., Kunimoto, M., Sato-Okabayashi, Y., Akita, K., Isoda, K., and Daida, H. Possible role of NADPH oxidase 4 in angiotensin II-induced muscle wasting in mice. Front. Physiol. 9, 340 (2018) Kawaguchi, T., Niba, ETE., Rani, AQM., Onishi, Y., Koizumi, M., Awano, H., Matsumoto, M., Nagai, M., Yoshida, S., Sakakibara, S., Maeda, N., Sato, O., Nishio, H., and Matsuo, M. Detection of dystrophin Dp71 in human skeletal muscle using an automated capillary Western assay system. Int J Mol Sci. 19, 1546 (2018) Harahap, NIF., Niba, ETE., Ar Rochmah, M., Wijaya, YOS., Saito, T., Saito, K., Awano, H., Morioka, I., Iijima, K., Lai, PS., Motsuo, M., Nishio, H., and Shinohara, M. Intron-retained transcripts of the spinal muscular atrophy genes, SMN1 and SMN2. Brain Dev. 40, 670-677 (2018) Hashimoto, R., Daida, H., Okada, T., and Katoh, Y.  A simple method to increase the proportion of bone marrow-derived macrophages positive for M-CSFR using the reducing agent dithiothreitol (DTT).  MethodsX 5, 1540 (2018) 2017 Kometani, M., Yoneda, T., Demura, M., Koide, H., Nishimoto, K., Mukai, K., Gomez-Sanchez, C.E., Akagi, T., Yokota, T., Horike, S.I., Karashima, S., Miyamori, I., Yamagishi, M., and Takeda, Y. Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia. Sci. Rep. 7, 11205 (2017) Nagaoka, M., Yashiro, T., Uchida, Y., Ando, T., Hara, M., Arai, H., Ogawa, H., Okumura, K., Kasakura, K., and Nishiyama, C. The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells. J. Immunol. 199, 2958-2967 (2017) Yashiro, T., Kasakura, K., Oda, Y., Kitamura, N., Inoue, A., Nakamura, S., Yokoyama, H., Fukuyama, K., Hara, M., Ogawa, H., Okumura, K., Nishiyama, M., and Nishiyama, C. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int. Immunol. 29, 87-94 (2017) Kawauchi, T., Ishimaru, K., Nakamura, Y., Nakano, N., Hara, M., Ogawa, H., Okumura, K., Shibata, S., and Nakao, A. Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergol. Int. 66, 472-478 (2017) Honjo, A., Nakano, N., Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T. Pharmacologic inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J. Allergy Clin. Immunol. 139, 987-996 (2017) Niba, ETE., Ar Rochmah, M., Harahap, NIF., Awano, H., Morioka, I., Iijima, K., Saito, T., Saito, K., Takeuchi, A., Lai, PS., Bouike, Y., Nishio, H., and Shinohara, M. SMA diagnosis: Detection of SMN1 deletion with real-time mCOP-PCR system using fresh blood DNA. Kobe J Med Sci. 63, E80-E83 (2017) Niba, ETE., Yamanaka, R., Rani, AQM., Awano, H., Matsumoto, M., Nishio, H., and Matsuo, M. DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification. Cancer Cell Int. 17, 58 (2017) Niba, ETE., Nishida, A., Tran, VK., Vu, DC., Matsumoto, M., Awano, H., Lee, T., Takeshima, Y., Nishio, H., and Matsuo, M. Cryptic splice activation but not exon skipping is observed in minigene assays of dystrophin c.9361+1G>A mutation identified by NGS. J Hum Genet. 62, 531-537 (2017) Ar Rochmah, M., Harahap, NIF., Niba, ETE., Nakanishi, K., Awano, H., Morioka, I., Iijima, K., Saito, T., Saito, K., Lai, PS., Takeshima, Y., Takeuchi, A., Bouike, Y., Okamoto, M., Nishio, H., and Shinohara, M. Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Brain Dev. 39, 774-782 (2017) Ar Rochmah, M., Shima, A., Harahap, NIF., Niba, ETE., Morisada, N., Yanagisawa, S., Saito, T., Kaneko, K., Saito, K., Morioka, I., Iijima, K., Lai, PS., Bouike, Y., Nishio, H., and Shinohara, M. Gender effects on the clinical phenotype in Japanese patients with spinal muscular atrophy. Kobe J Med Sci. 63, E41-E44 (2017) Shinohara, M., Ar Rochmah, M., Nakanishi, K., Harahap, NIF., Niba, ETE., Saito, T., Saito, K., Takeuchi, A., Bouike, Y., and Nishio, H. New, improved version of the mCOP-PCR screening system for detection of spinal muscular atrophy Gene (SMN1) deletion. Kobe J Med Sci. 63, E37-E40 (2017) Hashimoto, R., Joshi, S., Jiang, H., Capdevila, J., McMurtry, I., Schwartzman, M., and Gupte, S.  Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: Implication in chronic hypoxia-induced pulmonary hypertension.  Am. J. Physiol. Heart Circ. Physiol. 313, H293 (2017) Hashimoto, R., Kakigi, R., Nakamura, K., Itoh, S., Daida, H., Okada, T., and Katoh, Y.  LPS enhances expression of CD204 through the MAPK/ERK pathway in murine bone marrow macrophages.  Atherosclerosis 266, 167 (2017) Hashimoto, R., Katoh, Y., Miyamoto, Y., Nakamura, K., Itoh, S., Daida, H., Nakazato, Y., and Okada, T.  High extracellular Ca²&＃8314; enhances the adipocyte accumulation of bone marrow stromal cells through a decrease in cAMP.  Cell Calcium 67, 74 (2017) 2016 Uranishi, K., Akagi, T., Koide, H., and Yokota, T.  Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.  Biochem. Biophys. Res. Commun.  478, 1720-1725 (2016) Tabe, Y., Hatanaka, Y., Nakashiro, M., Sekihara, K., Yamamoto, S., Matsushita, H., Kazuno, S., Fujimura, T., Ikegami, T., Nakanaga, K., Matsumoto, H., Ueno, T., Aoki, J., Yokomizo, T., Konopleva, M., Andreeff, M., Miida, T., Iwabuchi, K., and Sasai, K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int. J. Radiat. Biol. 92, 24-34(2016) Someya, A., Ikegami, T., Sakamoto, K., and Nagaoka, I. Glucosamine Downregulates the IL-1 beta-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and - Independent Mechanisms. PLoS One. 11, e0165158 (2016) Suzuki, M., Hara, M., Ichikawa, S., Kamijo, S., Nakazawa, T., Hatanaka, H., Akiyama, K., Ogawa, H., Okumura, K., and Takai, T. Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice. Allergol. Int. 65, 44-51 (2016) Shimura, S., Takai, T., Iida, H., Maruyama, N., Ochi, H., Kamijo, S., Nishioka, I., Hara, M., Matsuda, A., Saito, H., Nakae, S., Ogawa, H., Okumura, K., and Ikeda, S. Epicutaneous allergic sensitization by cooperation between allergen protease activity and mechanical skin barrier damage in mice. J. Invest. Dermatol. 136, 1408-1417 (2016) Kamijo, S., Suzuki, M., Hara, M., Shimura, S., Ochi, H., Maruyama, N., Matsuda, A., Saito, H., Nakae, S., Suto, H., Ichikawa, S., Ikeda, S., Ogawa, H., Okumura, K., and Takai, T. Subcutaneous allergic sensitization to protease allergen is dependent on mast cells but not IL-33: Distinct mechanisms between subcutaneous and intranasal routes. J. Immunol. 196, 3559-3569 (2016) Miura, R., Kasakura, K., Nakano, N., Hara, M., Maeda, K., Okumura, K., Ogawa, H., Yashiro, T., and Nishiyama, C. Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells. PLoS One. 11, e0154094 (2016) Yashiro, T., Hara, M., Ogawa, H., Okumura, K., and Nishiyama, C. Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells. Sci. Rep. 6, 34825 (2016) Nishida, A., Yasuno, S., Takeuchi, A., Awano, H., Lee, T., Niba, ET., Fujimoto, T., Itoh, K., Takeshima, Y., Nishio, H., and Matsuo, M. HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab. Histochem Cell Biol. 146, 301-309 (2016) 2015 Akagi, T., Kuure, S., Uranishi, K., Koide, H., Costantini, F., and Yokota, T. ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in ES cells. J. Biol. Chem. 290, 22460-22473 (2015) Tada, Y., Yamaguchi, Y., Kinjo, T., Song, X., Akagi, T., Takamura, H., Ohta, T., Yokota, T., and Koide, H. The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells. Oncogene 34, 752-760 (2015) Kanai, D., Ueda, A., Akagi, T., Yokota, T., and Koide, H. Oct3/4 directly regulates expression of E2F3a in mouse embryonic stem cells. Biochem. Biophys. Res. Commun. 459, 374-378 (2015) Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H. Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J. Immunol. 194, 4535-4544 (2015) Ishiyama, K., Yashiro, T., Nakano, N., Kasakura, K., Miura, R., Hara, M., Kawai, F., Maeda, K., Tamura, N., Okumura, K., Ogawa, H., Takasaki, Y., and Nishiyama, C. Involvement of PU.1 in NFATc1 promoter function in osteoclast development. Allergol. Int. 64, 241-247 (2015) Yamazaki, S., Nakano, N., Honjo, A., Hara, M., Maeda, K., Nishiyama, C., Kitaura, J., Ohtsuka, Y., Okumura, K., Ogawa, H., and Shimizu, T. The transcription factor Ehf is involved in TGF-β-induced suppression of FcεRI and c-kit expression and FcεRI-mediated activation in mast cells. J. Immunol. 195, 3427-3435 (2015) Nishida, A., Minegishi, M., Takeuchi, A., Awano, H., Niba, ET., and Matsuo, M. Neuronal SH-SY5Y cells use the C-dystrophin promoter coupled with exon 78 skipping and display multiple patterns of alternative splicing including two intronic insertion events. Hum Genet. 134, 993-1001 (2015) Nishida, A., Minegishi, M., Takeuchi, A., Niba, ET., Awano, H., Lee, T., Iijima, K., Takeshima, Y., and Matsuo, M. Tissue- and case-specific retention of intron 40 in mature dystrophin mRNA. J Hum Genet. 60, 327-333 (2015) Hashimoto, R., Nakamura, K., Itoh, S., Daida, H., Nakazato, Y., Okada, T., and Katoh, Y.  Bone marrow-derived regenerated smooth muscle cells have ion channels and properties characteristic of vascular smooth muscle cells. Journal of Stem Cell Research & Therapy 5, 257 (2015) Hashimoto, R., Katoh, Y., Miyamoto, Y., Itoh, S., Daida, H., Nakazato, Y., and Okada, T.  Increased extracellular and intracellular Ca²&＃8314; lead to adipocyte accumulation in bone marrow stromal cells by different mechanisms. Biochem. Biophys. Res. Commun. 457, 647 (2015) 2014 Yamaguchi, Y., Takamura, H., Tada, Y., Akagi, T., Oyama, K., Miyashita, T., Tajima, H., Kitagawa, H., Fushida, S., Yokota, T., Ohta, T., and Koide, H. Nanog positively regulates Zfp57 expression in mouse embryonic stem cells. Biochem. Biophys. Res. Commun. 453, 817-820 (2014) Doe, K., Nozawa, K., Hiruma, K., Yamada, Y., Matsuki, Y., Nakano, S., Ogasawara, M., Nakano, H., Ikeda, T., Ikegami, T., Fujishiro, M., Kawasaki, M., Ikeda, K., Amano, H., Morimoto, S., Ogawa, H., Takamori, K., Sekigawa, I. and Takasaki, Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. Lupus 23, 1031-1041 (2014) Nakamura, Y., Nakano, N., Ishimaru, K., Hara, M., Ikegami, T., Tahara, Y., Katoh, R., Ogawa, H., Okumura, K., Shibata, S., Nishiyama, C., and Nakao, A. Circadian regulation of allergic reactions by the mast cell clock in mice. J. Allergy Clin. Immunol. 133, 568-575 (2014) Takai, T., Chen, X., Xie, Y., Vu, A.T., Le, T.A., Kinoshita, H., Kawasaki, J., Kamijo, S., Hara, M., Ushio, H., Baba, T., Hiramatsu, K., Ikeda, S., Ogawa, H., and Okumura, K. TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol. 535, 371-387 (2014) Kiatsurayanon, C., Niyonsaba, F., Smithrithee, R., Akiyama, T., Ushio, H., Hara, M., Okumura, K., Ikeda, S., Ogawa, H. Host defense (Antimicrobial) peptide, human β-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes. J. Invest. Dermatol. 134, 2163-2173 (2014) Inage, E., Kasakura, K., Yashiro, T., Suzuki, R., Baba, Y., Nakano, N., Hara, M., Tanabe, A., Oboki, K., Matsumoto, K., Saito, H., Niyonsaba, F., Ohtsuka, Y., Ogawa, H., Okumura, K., Shimizu, T., and Nishiyama, C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J. Immunol. 192, 3936-3946 (2014) Aihara, Y., Oh-oka, K., Kondo, N., Sharma, J., Shrestha, N.C., Ishimaru, K., Hara, M., Yamagata, Z., Nakao, A. Residential area, birth order, and dietary habit may influence TSLP levels in colostrum: comparative study between Japan and Nepal. Allergol. Int. 63, 283-285 (2014) Koide, H. Embryonic stem cells and oncogenes. in Pluripotent Stem Cell Biology - Advances in Mechanisms, Methods and Models (Craig S. Atwood & Sivan Vadakkadath Meethal eds.) pp 41-61, InTech (2014) Aihara, Y., Oh-oka, K., Kondo, N., Sharma, J., Ishimaru, K., Hara, M., Yamagata, Z., and Nakao, A. Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal. Asian Pac J Allergy Immunol. 32, 178-184 (2014) Niba, ET., Tran, VK., Tuan-Pham, le A., Vu, DC., Nguyen, NK., Ta, VT., Tran, TH., Lee, T., Takeshima, Y., and Matsuo, M. Targeted next-generation sequencing reveals a homozygous nonsense mutation in CAPN3 that causes limb-girdle muscular dystrophy type 2A first in Vietnam. J Mol Biomark Diagn. 5, 1000194 (2014). Niba, ET., Tran, VK., Tuan-Pham, le A., Vu, DC., Nguyen, NK., Ta, VT., Tran, TH., Lee, T., Takeshima, Y., and Matsuo, M. Validation of ambiguous MLPA results by targeted next-generation sequencing reveals a nonsense mutation in the DMD gene. Clin Chim Acta. 436, 155-159 (2014) 2013 Uranishi, K., Akagi, T., Sun, C., Koide, H., and Yokota, T. Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Mol. Cell. Biol. 33, 2056-2066 (2013) Fujii, Y., Kakegawa, M., Koide, H., Akagi, T., and Yokota, T. Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator. Biochem. Biophys. Res. Commun. 441, 411-417 (2013) Tsutsumi, S., Ogino, I., Miyajima, M., Ikeda, T., Shindo, N., Yasumoto, Y., Ito, M., and Arai, H. Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J. Clin. Neurosci. 20, 667-669 (2013) Ito, M., Kajino, K., Abe, M., Fujimura, T., Mineki, R., Ikegami, T., Ishikawa, T., and Hino, O. NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncol. Rep. 29, 1492-500 (2013) Hara, M., Yokoyama, H., Fukuyama, K., Kitamura, N., Shimokawa, N., Maeda, K., Kanada, S., Ito, T., Usui, Y., Ogawa, H., Okumura, K., Nishiyama, M., and Nishiyama, C. Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells. Mol. Immunol. 53, 295-301 (2013) Kamijo, S., Takeda, H., Tokura, T., Suzuki, M., Inui, K., Hara, M., Matsuda, H., Matsuda, A., Oboki, K., Ohno, T., Saito, H., Nakae, S., Sudo, K., Suto, H., Ichikawa, S., Ogawa, H., Okumura, K., and Takai, T. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J. Immunol. 190, 4489-4499 (2013) Niba, ET., Nagaya, H., Kanno, T., Tsuchiya, A., Gotoh, A., Tabata, C., Kuribayashi, K., Nakano, T., and Nishizaki, T. Crosstalk between PI3 kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK pathways downstream PDGF receptor. Cell Physiol Biochem. 31, 905-913 (2013) 2012 Tavares, L., Dimitrova, E., Oxley, D., Webster, J., Poot, R., Demmers, J., Bezstarosti, K., Taylor, S., Ura, H., Koide, H., Wutz, A., Vidal, M., Elderkin, S., and Brockdorff, N. RYBP-PRC1 complexes mediate H2A ubiquitylation at Polycomb target sites independently of PRC2 and H3K27me3. Cell 148, 664-678 (2012) Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, J.H., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, Y.W., and Nakano, H. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci. Signal. 5, ra93 (2012) Ohtsuka, Y., Ikegami, T., Izumi, H., Namura, M., Ikeda, T., Ikuse, T., Baba, Y., Kudo, T., Suzuki, R., and Shimizu, T. Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine. Pediatr. Res. 71, 46-53 (2012) Potaczek, D.P., Kamijo, M., Hara, M., Okumura, K., Undas, A., and Nishiyama, C. A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations. Mol. Biol. Rep. 39, 3747-3753 (2012) Kitamura, N., Yokoyama, H., Yashiro, T., Nakano, N., Nishiyama, M., Kanada, S., Fukai, T., Hara, M., Ikeda, S., Ogawa, H., Okumura, K., and Nishiyama, C. Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J. Allergy Clin. Immunol. 129, 814-824 (2012) Baba, Y., Maeda, K., Yashiro, T., Inage, E., Niyonsaba, F., Hara, M., Suzuki, R., Ohtsuka, Y., Shimizu, T., Ogawa, H., Okumura, K., and Nishiyama, C. Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. Allergol. Int. 61, 461-467 (2012) Baba, Y., Maeda, K., Yashiro, T., Inage, E., Kasakura, K., Suzuki, R., Niyonsaba, F., Hara, M., Tanabe, A., Ogawa, H., Okumura, K., Ohtsuka, Y., Shimizu, T., and Nishiyama, C. GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. Biol. Chem. 287, 32689-32696 (2012) Hashimoto, R., Katoh, Y., Nakamura, K., Itoh, S., Iesaki, T., Daida, H., Nakazato, Y., and Okada, T.  Enhanced accumulation of adipocytes in bone marrow stromal cells in the presence of increased extracellular and intracellular [Ca²&＃8314;].  Biochem. Biophys. Res. Commun. 423, 672 (2012) 2011 Ura, H., Murakami, K., Akagi, T., Kinoshita, K., Yamaguchi, S., Masui, S., Niwa, H., Koide, H., and Yokota, T. Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation. EMBO J. 30, 2190–2204 (2011) Kelly, K.F., Ng, D.Y., Jayakumaran, G., Wood, G.A., Koide, H., and Doble, B.W. β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell 8, 214-227 (2011) Kanada, S., Nishiyama, C., Nakano, N., Suzuki, R., Maeda, K., Hara, M., Kitamura, N., Ogawa, H., and Okumura, K. Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood 117, 2211-2222 (2011) Nakamura, Y., Harama, D., Shimokawa, N., Hara, M., Suzuki, R., Tahara, Y., Ishimaru, K., Katoh, R., Okumura, K., Ogawa, H., Shibata, S., and Nakao, A. Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction. J. Allergy Clin. Immunol. 127, 1038-1045 (2011) Vu, A.T., Chen, X., Xie, Y., Kamijo, S., Ushio, H., Kawasaki, J., Hara, M., Ikeda, S., Okumura, K., Ogawa, H., and Takai, T. Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB- dependent pathway in human keratinocytes. Invest. Dermatol. 131, 2205-2212 (2011) Nishida, C., Tomita, T., Nishiyama, M., Suzuki, R., Hara, M., Itoh, Y., Ogawa, H., Okumura, K., and Nishiyama, C. B-transferase with a Pro234Ser substitution acquires AB-transferase activity. Biosci. Biotechnol. Biochem. 75, 1570-1575 (2011) Koide, H., and Yokota, T. The LIF/STAT3 pathway in ES cell self-renewal. in Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis (Craig S. Atwood, ed.) pp 61-78, InTech (2011) Click here to view publications before 2011 2010 Miura, M., Ueda, A., Takao, Y., Koide, H., and Yokota, T. A stem cell-derived gene, Sddr, negatively regulates differentiation of embryonic stem cells. Int. J. Dev. Biol. 54, 33-39 (2010) Yamada, K., Kobayashi, N., Ikeda, T., Suzuki, Y., Tsuge, T., Horikoshi, S., Emancipator, S.N., and Tomino, Y. Down-regulation of core 1 β1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1. Nephrol. Dial. Transplant. 25, 3890-3897 (2010) Kunogi, M., Kurihara, M., Shigihara-Ikegami, T., Kobayashi, T., Shindo, N., Kumasaka, T., Gunji, Y., Kikkawa, M., Iwakami, S., Hino, O., Takahashi, K., and Seyama, K. Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature. J. Med. Genet. 47, 281-287 (2010) Niyonsaba, F., Ushio, H., Hara, M., Yokoi, H., Tominaga, M., Takamori, K., Kajiwara, N., Saito, H., Nagaoka, I., Ogawa, H., and Okumura, K. Antimicrobial peptides human β-Defensins and Cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J. Immunol. 184, 3526-3534 (2010) Wang, Q.H., Nishiyama, C., Nakano, N., Kanada, S., Hara, M., Kitamura, N., Shimokawa, N., Lu, C.L., Ogawa, H., and Okumura, K. Opposite effects of Trichostatin A on activation of mast cells by different stimulants. FEBS Lett. 584, 2315-2320 (2010) Shimokawa, N., Nishiyama, C., Nakano, N., Maeda, K., Suzuki, R., Hara, M., Fukai, T., Tokura, T., Miyajima, H., Nakao, A., Ogawa, H., and Okumura, K. Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics 62, 421-429 (2010) Nishida, C., Nishiyama, C., Satoh, K., Hara, M., Itoh, Y., Ogawa, H., and Okumura, K. Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells. Leg. Med. (Tokyo) 12, 172-176 (2010) Hashimoto, R., Katoh, Y., Itoh, S., Iesaki, T., Daida, H., Nakazato, Y., and Okada, T.  T-Type Ca²&＃8314; channel blockers increase smooth muscle progenitor cells and endothelial progenitor cells in bone marrow stromal cells in culture by suppression of cell death.  Annals of Vascular Diseases 3, 117 (2010) 2009 Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Ko, M.S.H., Niwa, H., and Yokota, T. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Mol. Cell. Biol. 29, 4574-4583 (2009) Yamauchi, J., Miyamoto, Y., Torii, T., Mizutani, R., Nakamura, K., Sanbe, A., Koide, H., Kusakawa, S., and Tanoue, A. Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells. Exp. Cell Res. 315, 2043-2052 (2009) Luo, S.S., Ishibashi, O., Ishikawa, G., Ishikawa, T., Katayama, A., Mishima, T., Takizawa, T., Shigihara, T., Goto, T., Izumi, A., Ohkuchi, A., Matsubara, S., Takeshita, T., and Takizawa, T. Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes. Biol. Reprod. 81, 717-729 (2009) Kinoshita, H., Takai, T., Le, T.A., Kamijo, S., Wang, X.L., Ushio, H., Hara, M., Kawasaki, J., Vu, A.T., Ogawa, T., Gunawan, H., Ikeda, S., Okumura, K., and Ogawa, H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol. 123, 179-186 (2009) Ito, T., Nishiyama, C., Nakano, N., Nishiyama, M., Usui, Y., Takeda, K., Kanada, S., Fukuyama, K., Akiba, H., Tokura, T., Hara, M., Tsuboi, R., Ogawa, H., and Okumura, K. Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-γ. Int. Immunol. 21, 803-816 (2009) Fukai, T., Nishiyama, C., Kanada, S., Nakano, N., Hara, M., Tokura, T., Ikeda, S., Ogawa, H., and Okumura, K. Involvement of PU.1 in the transcriptional regulation of TNF-α. Biochem. Biophys. Res. Commun. 388, 102-106 (2009) Potaczek, D.P., Maeda, K., Wang, Q.H., Nakano, N., Kanada, S., Stepien, E., Branicka, A., Fukai, T., Hara, M., Tokura, T., Ogawa, H., Undas, A., Okumura, K., and Nishiyama, C. FcεRIα gene -18483A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics 61, 649-655 (2009) 2008 Ura, H., Usuda, M., Kinoshita, K., Sun, C., Mori, K., Akagi, T., Matsuda, T., Koide, H., and Yokota, T.  STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.  J. Biol. Chem.283, 9713-9723 (2008) Sun, C., Nakatake, Y., Ura, H., Akagi, T., Niwa, H., Koide H., and Yokota, T.  Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.  Biochem. Biophys. Res. Commun. 372, 91-96 (2008) Kawasaki, K., Watabe, T., Sase, H., Hirashima, M., Koide, H., Morishita, K., Yuki, K., Sasaoka, T., Suda, T., Katsuki, M., Miyazono, K., and Miyazawa, K.  Ras signaling specifies endothelial differentiation of VEGFR2+ vascular progenitor cells.  J. Cell Biol.181, 131-141 (2008) Shigihara, T., Hashimoto, M., Shindo, N., and Aoki, T.  Transcriptome profile of Trypanosoma cruzi-infected cells: simultaneous up- and down-regulation of proliferation inhibitors and promoters.  Parasitol Res. 102, 715-722 (2008) Ishikawa, Y., Tokura, T., Nakano, N., Hara, M., Niyonsaba, F., Ushio, H., Yamamoto, Y., Tadokoro, T., Okumura, K., and Ogawa, H.  Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro.  J. Med. Food 11, 14-20 (2008) Wang, Q.H., Nishiyama, C., Nakano, N., Shimokawa, N., Hara, M., Kanada, S., Ogawa, H., and Okumura, K. Suppressive effect of Elf-1 on FceRI a-chain expression in primary mast cells.  Immunogenetics 60, 557-563 (2008) 2007 Takao, Y., Yokota, T., and Koide, H.  β-Catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells.  Biochem. Biophys. Res. Commun. 353, 699-705 (2007) Kinoshita, K., Ura, H., Akagi, T., Usuda, M., Koide, H., and Yokota, T.  GABPα regulates Oct-3/4 expression in mouse embryonic stem cells.  Biochem. Biophys. Res. Commun. 353, 686-691 (2007) Tadokoro, H., Shigihara, T., Ikeda, T., Takase, M., and Suyama, M.  Two distinct pathways of p16 gene inactivation in gallbladder cancer.  World J. Gastroenterol. 47, 6396-6403 (2007) Chen, X., Niyonsaba, F., Ushio, H., Hara, M., Yokoi, H., Matsumoto, K., Saito, H., Nagaoka, I., Ikeda, S., Okumura, K., and Ogawa, H.  Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.  Immunol. 37, 434-444 (2007) Gondokaryono, S.P., Ushio, H., Niyonsaba, F., Hara, M., Takenaka, H., Jayawardana, S.T., Ikeda, S., Okumura, K., and Ogawa, H.  The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4.  J. Leukoc. Biol. 82, 657-665 (2007) 2006 Setoguchi, Y., Ikeda, T., and Fukuchi, Y.  Clinical features and genetic analysis of surfactant protein C in adult-onset familial interstitial pneumonia.  Respirology 11, S41-45 (2006) -->  Introduction   Research   Publications   Laboratory  Japanese     Index To Page Top Juntendo University Copyright &＃64; 2011 JUNTENDO All Rights Reserved.